a mixture of cocaine, heroin, and LSD. a variation on the classic speedball, which is simply a mixture of cocaine and heroin for intravenous injection. taken from the idea that LSD was first widely popular in the Haight-Ashbury section of San Francisco in the 1960's.
I really don't think anybody does Frisco Speedballs anymore, and that's just sad.
A sexual situation involving three men or three women, mostly metaphorical. Literally, it is a sexual position in such a gathering where one person receives sexual stimulation from one person below them, and the other participant above them. A homosexualthreesome.
After getting his two guy friends drunk, Darian couldn't wait to be the meat in a frisco sandwich.