Top definition
1.a crazy motherfucker. 2. A devoted fan of Slightly Stoopid and member of their street team.
G: "Stop playing around wit me son or I'm gonna slit open yo bitch ass gizzad..."

Juan: "Hey take it easy homes! No need to act all ese loco n' shit."

or

Stoner Sam: Hey bro, you going to see Stoopid in Philly?

Harry Hed: Fuck ya, I'm an ese loco so I get backstage passes!
by AcidHead October 26, 2007
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