eff off Share definition Flag Retaliatory remark made by someone who is too much of a pussy to say FUCK OFF I don't drink, smoke, do drugs, have sex, eat meat or swear. If you don't like that, then eff off, ya big weenie! eff off by Anonymous October 10, 2003 0 0 Get merch Get the eff off mug. Buy Now — $32.95 See more merch