Vomiting while kneeling and holding onto the rim of the toilet. So called because it resembles grasping the large horizontal steering wheel of a bus.
Last night after eight beers and an Irish coffee I spent an hour in the bathroom driving the bus.
by Albin Pahernik August 31, 2005
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Throwing up (vomiting) into a toilet. So-called because your firm grasp on the rim resembles the bus-driver clutching his/her steering wheel.
The heat, the food, and the drinks combined in a bad way. I ran inside from the barbeque and started driving the bus.
by GoFigure September 2, 2005
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To vomit kneeling in front of the bowl of a toilette. Because you are holding the bowl with your hands, it looks like you are driving a bus.
by Doppelstern April 8, 2009
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In the act of selling drugs, you end up driving around to several different places for very little profit.
"I'm driving the bus at this point since I've driven to Egypt and back all for a funky $20 profit!"
by MP$40 August 30, 2005
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Being in charge of a project or planned activity, whether work related or not.
WORK: “We need to all be on the same page with this project, so we need a good outline and a game plan.”
“What are you expecting me to do? You’re driving the bus!”

FREE TIME:“Hey, when are we meeting at the theater and which movie are we seeing?”
“Shoot, man, ask John. He’s driving the bus.”
by Nurse Kitten August 31, 2005
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When it is your turn to drive the carpool to work, school, sporting events, ect.
This is the week I am driving the bus to work so I know we will be on time for a change.
by Delow August 30, 2005
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the act of hurlage. Vomiting.

"Wow, was I ever driving the bus last night after that 5th Long Island Iced Tea"
by Zanner August 30, 2005
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