Top definition
(verb phrase, colloquial euphemism)

To die by suicide, chronic self-abuse or careless behavior.
We've brought you to the Crisis Intervention ward because you tried to do yourself in.

Slow down on the wet road, or you'll do yourself in.

Shooting heroin and coke together is a surefire recipe to do yourself in.
by rasputin1963 December 28, 2010
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