deff out 

A state of paranoia brought on by excessive alcohol or substances use.

That last pint made him totally 'deff out'.

deff out by Grizlord October 3, 2006

deff out 

to leave your friends to hang out with your boyfriend of girlfriend.

As soon as she started going out with Tony she completely deffed out and left Amanda.

deff out by maggie February 25, 2004