Top Definition
to leave your friends to hang out with your boyfriend of girlfriend.
As soon as she started going out with Tony she completely deffed out and left Amanda.
by maggie February 25, 2004
5 Words related to deff out
A state of paranoia brought on by excessive alcohol or substances use.
That last pint made him totally 'deff out'.
by Grizlord October 03, 2006

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