The act of throwing someone or something out of a window.
Helga: "What did you just do Bobby?!"
Bobby: "What can't I defenestrate my trash out on to the highway?"
Helga: "Are you retarded?! That's called littering, we could be fined!"
(Cue the police)
by Painthetownfred February 02, 2010
the defensive act of castrating someone in order to prevent sexual advances. First used in Questionable Content comic number 36.
I had to defenestrate my roommate before he tried to sleep with me.
by RoblingRobot November 10, 2009
to reduce to utter ruin or nonexistence; destroy utterly; to molliwhop something real nice
After the Mark made a comment about Sean's sister, Sean defenestrated him. Mark was last seen missing two teeth and with a nice shiner.
by Soheil Saeed February 26, 2008
To quickly close a computer window so as to prevent your boss/girlfriend/etc. from seeing it.
I was checking out some hot girl on girl porn on the internet when my girl suddenly came home and I had to defenestrate it right quick.
by Windoze XP March 25, 2005
To uninstall software from a Microsoft operating system, usually in frustration.
I couldn't get that program to do what I needed it to, so I defenestrated it and installed something better.
by jsgarvin September 23, 2010

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