the defensive act of castrating someone in order to prevent sexual advances. First used in Questionable Content comic number 36.
I had to defenestrate my roommate before he tried to sleep with me.
by RoblingRobot November 10, 2009
to reduce to utter ruin or nonexistence; destroy utterly; to molliwhop something real nice
After the Mark made a comment about Sean's sister, Sean defenestrated him. Mark was last seen missing two teeth and with a nice shiner.
by Soheil Saeed February 26, 2008
To quickly close a computer window so as to prevent your boss/girlfriend/etc. from seeing it.
I was checking out some hot girl on girl porn on the internet when my girl suddenly came home and I had to defenestrate it right quick.
by Windoze XP March 25, 2005
To uninstall software from a Microsoft operating system, usually in frustration.
I couldn't get that program to do what I needed it to, so I defenestrated it and installed something better.
by jsgarvin September 23, 2010
To throw something out of a large window.
"My God man, if you don't SHUT UP, I will defenestrate you."
by Awesome Socks Man Boy Kid Guy September 09, 2014

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