conveys worry, pain, distress, fear, or any negative/unpleasant emotion.
Ayyo! I have a test in 2 hrs!
Ayyo! my head hurts!
Ayyo! my life sucks!
by malluXXX September 30, 2010
When something very homosexual pops off in front of you.
Jaden: Son, I heard dat guy slobbed some dude's pipe yesterday.

Tyrin: AY YO! Dat's foul son.
by J.C. Jones October 14, 2006

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