An aspie is one who has Asperger's Syndrome, which is believed to be part of the autism spectrum. Aspies, while being quite gifted verbally, have social, emotional, and sensory integration difficulties, among others. Aspie is an affectionate term, and is not meant as a put down.
My son is an aspie, so he's not so great at making idle chit chat at parties, or even at being in crowds, but he can get us home from anywhere. He says he just consults the map in his brain.
This term is an affectionate nickname for those with Asperger's syndrome. It was the idea of parents/relatives of aspies.
Aspies are healthy mentally, their brain's just wired a different way.
I am an Aspie. That is, a person with asperger's syndrome. Some of the definitions on asperger's on here are questionable at best, at worst, so ignorant as to be offensive.
Someone who claims to be an aspie ((the one that mentions a pill about the size of a tic-tac)) would be more believable had they omitted the clause of it being made up.