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An aspie is one who has Asperger's Syndrome, which is believed to be part of the autism spectrum. Aspies, while being quite gifted verbally, have social, emotional, and sensory integration difficulties, among others. Aspie is an affectionate term, and is not meant as a put down.
My son is an aspie, so he's not so great at making idle chit chat at parties, or even at being in crowds, but he can get us home from anywhere. He says he just consults the map in his brain.
aspie by Susan Taggart July 27, 2005
Related Words
he's an aspie
i don't like the phrase 'i am a person with aspergers', i call myself an aspie
Aspie by BearIncognito March 28, 2018

Aspiengirl 

a gorgeous female with Asperger’s Syndrome, in possession of a kick arse intellect!
An Aspiengirl doesn’t have to choose between being drop dead gorgeous and a Mensa member!
Aspiengirl by Aspie Crusader August 15, 2013
One afflicted with Asperger's Syndrome, a disorder on the autism spectrum.

The disorder causes social and often motor impairments but those who have it are often very intelligent and have particularly strong interests.

Used mostly among Aspies themselves.
"Most people don't realize the trouble an aspie has socially."
aspie by Dan Grover June 18, 2004
This term is an affectionate nickname for those with Asperger's syndrome. It was the idea of parents/relatives of aspies.

Aspies are healthy mentally, their brain's just wired a different way.
I am an Aspie. That is, a person with asperger's syndrome. Some of the definitions on asperger's on here are questionable at best, at worst, so ignorant as to be offensive.

Someone who claims to be an aspie ((the one that mentions a pill about the size of a tic-tac)) would be more believable had they omitted the clause of it being made up.
Aspie by Walking Talking Dictionary September 11, 2006
Short for appetizers.
Are they going to bring appies to the party?
Appies by AndyBozac December 27, 2017