When female entryism has reached critical mass.
Critical mass = the numbers needed to control the environment, and get everything they want.
Everything they want = the sum of the Karens involved.
When an average looking man picks up the most beautiful girl at the party, only to get her home and find that her penis is bigger than his.
Joe: Dude, did you see who Bill left with?
Dude: You mean that tranny Jill?
Joe:Jill is a tranny?
Dude: Yes, and Bill is in for a serious case of vagirony.
A term commonly used in golf to describe a club (usually a mid or long iron) selected out of utter fear of hitting the more logical, powerful driver which the hole intends. A cowardly move at best, the decision rarely goes unnoticed by the other players who are compelled to mock and chastise the individual, even to go as far as questioning his gender.
Mike, lacking self-confidence, selects a vagiron to hit his tee shot on the wide-open par 5 as the rest of his foursome looks on in disbelief and bewilderment, for they can't comprehend such an embarrassing decision. Laughs ensue.
When after sexual intercourse (he) is hit by a wave of immense relaxation and tiredness brought fourth by being completely satisfied from being deep in (she) vagina, comparable to the sleepiness one experiences when taking Melatonin.
Man: "Damn, my girl hit me with that Vagitonin last night, I slept through all twelve of my alarms, the eviction notice being nailed to the door, a shooting at my apartments and just woke up (@5pm)"
With her keen sense of vagirony, Sarah Silverman was able to tell a story about her nastyyellow discharge that made her endearing to an even larger number of horny men.