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The same gesture as the famous High five but a more friendly term that can be exclaimed without making one look/sound like a high-fiving douche bag.
"So these frat boys in their Lexus' tried racing me in my VW, and I totally let them blow past just to watch the cops pull them over... Up Five!"

in lieu of an after-sex high five: "YEAH! I just banged the shit out of you! Up Five!"
Up Five by Dan Ray May 23, 2008
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wadded up five 

Represents a poor gesture, like giving someone a crumpled five-dollar bill for their hard work. Typically used to say that you wouldn't be that grateful for something.
If you mowed my lawn for me, I'd give you... a wadded up five? I'll probably just do it myself.
wadded up five by obeliskian July 10, 2025
To spend an entire night together and not miss a single high-five.

Comes from the idea that people spending time together will have fun and give each other high fives. Since the geek culture boom in the 80's, it's become much easier for a high-five to miss. If one avoids this tragic accident of pop culture, one has been said to be "five-up."
There was a minute there when I thought Brad was going to miss my hand, but he made it, so we were five-up.
five-up by Cap'n Awesome May 2, 2005
To meet with a group of people; hangout.

Comes from carpooling where you get in groups of five to save gas.
We have to drive pretty far, so let's five-up at my place to save gas.

Hey, you wanna five-up at the mall to go shopping?

Let's five-up at my place to watch a movie.
five-up by heads up five up April 24, 2011

win up to five times

Or LOSE up to ALL times!
If you buy five of the scratch-off tickets that say, "Win up to five times", it very likely will refer to how many times the STATE will win, since you were idiotic enough to spend the money on those five tickets and probably not win anything yourself.
win up to five times by QuacksO September 12, 2019

Five fingers up 

If you see a person popping fives they mostly likely gay or get no money
Don’t pop 5s big 4s five fingers up are for pussys

Drop a bomb from five foot up 

In act in which one stands upon the toilet seat and proceeds to release a giant turd into the toilet. Amateurs make a large splash. Professionals make no splash. For some, this is better than sex.
"Dude! last night I want to drop a bomb from five foot up and it made no splash, but Granny was over."