Top Definition
When someone is really annoying you.
Mum: Hey Dave do the dishes!
Friend: Man your mom is giving you heaps to do
Dave: Yeah she's been 'up in my ass' all day
#up in my ass #up in my arse #ass #arse #annoyed #annoying #annoy
by Dogdevourer February 25, 2008
6 Words related to Up in my ass
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