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This is a nickname for the University of Illinois at Urbana-Champaign. Not to be confused with the University of Iowa ("UI" or simply "Iowa") or Indiana University ("IU"). This phrase carries with it a certain image/feel, as the University has built up a notable culture over its' century and one half existence and the phrase "U of I" quite possibly is the best label for that culture. The culture includes a passion for basketball, drinking holiday Unofficial, superb academics, and or course, a lot of orange.
College counselor: "Are you looking at U of I for college, Jimmy?"
Jimmy: "Of course I am! Its' culture is unbeatable."
by Subway142 March 02, 2013
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