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1.
The act of posting the same thing on your Twitter feed and Facebook status within moments.
Jeff: "Did you see James' Facebook status a minute ago about the NFL?"
Joe: "Yeah, and then he tweeted the exact same thing about 10 seconds later."
Jeff: "He must be getting TwitFaced again."
by jc2 August 11, 2011
 
2.
Tweeting crazy nonsense via Twitter
When you read a tweet and say... WTF? This guy must be totally twitfaced.
by oldfatguy May 01, 2009
 
3.
The act of posting excessive, regrettable tweets while drunk.
I can't believe I got so twit-faced last night I tweeted my ex.
by Dooners April 15, 2011