Top Definition
A mental condition, usually found in teenage girls, which causes them to have strange and erratic behavior for the sake of twilight.
John: Dude, did you hear about what my girlfriend did last night?
Bill: What happened?
John: She made out with a dog because it reminded her of Jacob Black.
Bill: Shit, that sucks, dude. Dump her; I think she has twilightitis.
by cadtel July 13, 2010
1 more definition
The strange condition where girlfriend will leave their perfectly acceptable male counterparts claiming that they'll never be as good as Edward Cullen
Brad: What happened to Joe's Girlfriend dude?
Barry: Oh Cindy, yeah, she got Twilightitis and dumped him.
Brad: Bummer, she was such a babe!
by TheBlackList January 11, 2010

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