Top Definition
A mental condition, usually found in teenage girls, which causes them to have strange and erratic behavior for the sake of twilight.
John: Dude, did you hear about what my girlfriend did last night?
Bill: What happened?
John: She made out with a dog because it reminded her of Jacob Black.
Bill: Shit, that sucks, dude. Dump her; I think she has twilightitis.
by cadtel July 13, 2010
The strange condition where girlfriend will leave their perfectly acceptable male counterparts claiming that they'll never be as good as Edward Cullen
Brad: What happened to Joe's Girlfriend dude?
Barry: Oh Cindy, yeah, she got Twilightitis and dumped him.
Brad: Bummer, she was such a babe!
by TheBlackList January 11, 2010

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