1) to be high on stimulant supplements(vitamins) or drugs.

2) to be hyperactive.
1) sugar, caffeine, monster drinks, sugar, earl gray tea, amphetamine, methamphetamine are examples of commonly used stimulants that can cause a person to be tweakin. They can become fast-moving, jittery and if on meth violently jumpy or shaky (trembling)

2) ADD/ADHD, natural high, sugar high, caffeine high can cause tweakin (hypetactivity) where you'll just be all over t he place moving fast.

when someone is hyperactive it doesnt mean they are under the influence of methamphetamine where meth high causes similar behaviour but is a different kind of hyper.
by skaterjack October 6, 2006
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when you buck on somebody or think somebody thinks youre always thinking about them.
that bitch was tweakin' on the haunting of conneticut she thank somebody always tryna haunt her ass.
by pinkmonkey August 29, 2009
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Seeing Change Within Oneself, and achieving goals that will make their life better.

Doing Any kind of action that can make your life or someone else's life better.

Derives from the Company Tweaklife
If you gradually are doing better in school, your Tweakin'.

One do charitable work, your Tweakin' for making someone else's day better and helping them.
by Head Tweaker' February 28, 2011
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A form of the word tweaking people use when they wanna sound sophisticated when surrounded with dumb mfs who're tweaking.
This mf been waffling on how he not addicted n then 5 mins without it he spazzing on the floor he tweakinating.
by Bigbootyblackfredrick October 9, 2023
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when cocaine begins to take over the central nervous system, and the body begins to shake mildly.
cocaine + jesus = tweakin'
by evolved. revolved. devolved. August 21, 2003
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Basically it means a nigga acting crazy or sum shi
"Nah you see that nigga over there staring at us, yeah brodiline tweakin
by JC play 4 keeps June 4, 2023
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