It is another word for a blunt, which is a cigar that is hollowed out and filled with cannabis. It is in reference to the myth of Medusa, where anyone that saw Medusa's face would be turned to stone. The blunt itself will get the person smoking it high, or "stoned".
Jeff was cold rolling a Medusa on his kitchen counter.

Austin asks his friend to pass the Medusa.
by kuppalli October 27, 2014
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And how do you defeat a Medusa?
Hym “And how do you defeat a Medusa? You hold up mirror.”
by Hym Iam October 20, 2022
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An extremely beautiful girl who happens to be bitchy from time to time.
Kacie is such a medusa.
by Me January 29, 2004
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In Greek Mythology she was a woman caught banging Poseidon of the altar of Athena. Athena got really pissed and made Medusa really ugly, with snakes for hair.
Medusa is one person that you don't wish to anger.
by Pagan chick June 2, 2005
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A piercing on the center of the upper lip, below the septum.
Medusas, are in fact, very painful. They are not very common, but can still be found adorned on the bodies of body modification culture.
She pierced her Medusa while at the Body Art Expo.
by myspace.com/4509496 August 22, 2007
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A free swimming infant form of sessile aquatic life. So called because of its whiplike protrusions which vaguely resemble the snakes that formed Medusa's hair.
"After self-fertilization, a single celled medusae is formed. This form is free to swim around, until it finds a suitable location, whereupon it will attach itself permanently and develop in to the sessile polyp form."
by Musashi November 26, 2004
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That one girl who if you look into her eyes even once, you'll start to fall for her. Lighter colored skin makes it worse, as it'll bring out the eyes more, making it more likely for you to fall.
Damien: Woah, who is she?
Jerry: Darlene? Don't get into her, she's modern day medusa. One look and you're hooked.
by Snake Forgot September 19, 2016
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