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A cultural reference to drawing dicks on table tops and other related surfaces. While it is immature and wrong, it can be, at times, hysterical. D's Up is usually a formal way of greeting someone who does this sort of thing.
Guy 1: "Hey man, what's up?"
Guy 2: "Hey yo, D's Up."
Guy 1: "Ah yes, D's Up indeed."
D's Up by Skittmier September 21, 2009
Related Words
An abbreviation for the words "super" and "duper" which, put together, increase the emphasis placed on how spectacular something is.
That was supdup fun!

It was supdup exciting when we went on the rollercoaster!
supdup by XTJK August 9, 2009