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1.
Best friend, buddy, or roommate that you do shrooms with. You can use this term to call your friends even if you don't do shrooms, or do shrooms with them. In other words, you can just be good friends with them and not do shrooms, or just not do shrooms with them, or you can. It goes either way. Alternatively, "shroomie" can just mean good friend.
Supp, shroomie?

OR:

Person 1: Watchya doin' this weekend?
Person 2: Oh not much, just chillin' with my shroomies.
by kittykatmeow! April 10, 2008