British slang for "Down Syndrome", also slang for "autism" in other areas of the UK.

This slang term was developed so that people could speak about it in public without offending those afflicted with either illness.
It is popular in the "Wales" region.
i'd hate to be afflicted with plex, that guy with plex can't even come up with anything on his own
by rus_IMN November 1, 2012
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The equivalent to a pussy usually used when a parent or guardian is around and you can't say "YOU'RE SUCH A PUSSY MARK JUST JUMP OFF THE DAMN TREE!"
"Mark is a huge plex he still doesn't like girls he thinks that they have cooties."
by jack anthony January 19, 2008
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Another word for "Floss". A twist on the word "flex". Means to show off fancy clothing, cars, jewelry, etc....
"I floss even though they hate me/ Pull up in Vette's/ Humvees and Jets/ Watch me Plex/" - from "I Shyne" by Killa
by Lil SB February 17, 2008
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you got problems or beef with somebody: 2.song by da peoples champ
i got plex with fool
by dbone January 4, 2006
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1) It is the term to describe the number of different combinations in Super Mario Maker.
2) The proper term for the number 10^12431.
If every player in Super Mario Maker were to work together to complete the Mario Plex, it would take over 567 years.
by henrik.cg August 7, 2017
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Hey Augi! why is Caroline in your bed?... Did you just have Sex in the Plex?
by Arby2013 October 17, 2009
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A person (usually male) that is confused about his sexuality
(English slang derived of carabian origin)

Poom: pussy, cunt, vagina, minge, snatch

Plex(ed): shortend word for Perplexed
If a male is being overly friendly with a person(s) of the same sex, You might refer to him as a "Poom Plex" or that he is "Poom Plexed"
by Greg Osborne (Rev) March 26, 2007
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