Top Definition
an Acronym for Pos Fuck It.
pretty much fuck it but in a spanish way
Word originated in the bay area in Richmond/San Pablo
guy 1: Lets go keep it
guy 2: PFI breh!
by mitchfromtherich November 11, 2010
Prepare for Intercourse

Prepare for Ice Cream.
"Yo man she is PFI"

"Yo man I am PFI"
by Nigga in the Hood January 29, 2012

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