The semi-sick, semi-high feeling you get when taking NyQuil as a sick person during winter just to stay semi-coherant. This feeling may make you believe you feel 10x better than you actually are and allow you to get in a full day's work, a load of laundry done, and several home repairs finished before falling into a bone- weary heap on your bed.
Betty: "Aren't you going to go home sick? You looked awful yesterday."
Jean: "Nope - I'm on a NyQuil High - I'm not going home until 6pm!"

or

Semester finals were coming up and was sick as a dog, so I got on a NyQuil High and studied all night long.
by Hazelnutmegan January 1, 2007
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The incapacity to ejaculate because excessive amounts of NyQuil has been consumed. Similar to Whiskey Dick.
Friend 1: Dude, I was totally going to beat one off last night, but couldn't because I pounded two shots of NyQuil.

Friend 2: So you blue balled yourself?

Friend 1: yeah man, NyQuil dick. It's even worse than whiskey dick.
by NyQuil Lover January 24, 2013
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“Used specifically for putting a person to rest permanently or temporarily, the choice is in the user’s hands of this fabled technique. People that use this technique suffer severe or fatal injuries after if their bodies cannot handle it’s immense power.
Person 1: Did you hear what happened to Andrew?
Person 2: No, what happened?
Person 1: Mikey hit him with the “Fabled NyQuil” and knocked him into the sun.
Person 2: Poor Andrew, I bet he’s probably waiting in line at the Heaven Gates.
The Fabled NyQuil is a technique of which is forbidden in some places due to it’s destructive nature to those who wield it and those who are attacked by it.
by Junohh January 4, 2021
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Pussy so bad it puts you to sleep
You hear that Adam fucked Julia?

Yeah he said she got that NyQuil pussy
by Axebutt456 November 30, 2019
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Sperm, seamen, cum, and the list goes on
23:32 fatbottmedgal: I can't seem to find the NyQuil... *pout*
23:33 chains1872000: i have some white nyquil to inject in you....
23:34 fatbottmedgal: mmmm oh is that so *blush*
23:34 chains1872000: hehehe, yes ma'am
by alester starr September 19, 2008
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On a boring night, you take 2 doses of Nyquil while at least one other buddy waits for you to sleep for at least 1 hour. Make sure to pick out a spot at least 10 feet from your bed. Your friend wakes you up and screams nyquil challenge as loud and as fast as he/she can and you run towards the spot you picked out and try to make it back to your bed and back without falling or passing out.
Bud - "DUDE!!! WAKE UP!! AGGGHHH!! NYQUIL CHALLENGE!!
You - "HUH!?! What??"
Bud - "NYQUIL!! NYQUIL!! RUN RUN RUN!!
You - "Oh S&^@! ughhh"

the end
by Sword147 November 24, 2009
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