Top Definition
NyQuil®, is a multi-symptom formula that claims to help relieve all of your major cold symptoms. It's available in 2 flavors: Cherry, and Green Death.

Several people have taken to using NyQuil® as a slang word for 'drunk' or 'high', and even as blame for minor bouts of insanity.
"NyQuil®: The nighttime sniffling, sneezing, coughing, aching, stuffy head, fever, I TOLD YOU TO PUT THE LOTION IN THE FUCKING BASKET, so you can rest medicine."
"Man, you need to lay off the NyQuil."
"Why?"
"Cause you're losing it."
by Anonymous January 23, 2005

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The legal alcohol, that kids can buy!
Go on kiddies, you know you want to.
by Leiko October 06, 2004

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Genius drug that can be used by rehabbing patients...attracts users with its big fucking Q.
"I don't do illegal drugs anymore. Now I just do the legal drugs. Tonight I'm on NyQuil and Sudafed. Let me tell you something, folks. Forget about cocaine and heroine. All you need is NyQuil and Sudafed"
by Me April 25, 2005

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A non-prescription liquid medicine for treating the common cold that contains alcohol and an anti-histamine that has particularly strong sedative effects. Taken at bedtime, it usually provides for a good sleep.
Brian took a dose of NyQuil and was asleep in 20 minutes.
by Marty January 07, 2005

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Term used to define someone who just got KNOCKED THE FUCK OUT!!!
"NYQUIL MUTHA FUCKAH!!"
by ElmoMonster September 17, 2012

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A good cold medicine, to bitch-slap a cold with. I killed a bottle of Nyquil in 2 days, and on my second bottle of it.
2 bottles of Nyquil keeps a doctor away. Don't drink it on the job, because you might fall out drunk in front of your boss, and co-workers. It happened to me, when they found me passed-out drunk in the breakroom. Robitussin sucks. Kiss your cold good bye!!!!!!!!!
by Saints February 10, 2007

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If someone has got a cough, the sniffles, sneeze and a sore throat, it all in all can be easily called "NyQuil", according to the Vicks product.
Mike behaves as if he has catched a virus from the movie-picture 'Outbreak', Sandy speaks smilingly into Shirley's ear.
Sure. He's always such a sissy. This guy just has got a classical NyQuil!, Mandy replies.
by Henning Mühlinghaus February 13, 2008

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