Short for nephew, used when addressing an acquaintance or friend
"Hey Tyrone, what's up my nef?"
by Sylkki August 2, 2006
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Oh man he just got hit by a car. He is fucked. No, no, he's neffed.
by AuntieJay April 17, 2010
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Not even funny, like when you are being sarcastic or hyper.
Hana: He broke up with you?

Jennifer: Yeah

Hana: You must be hurting. What did you do all day yesterday?

Jennifer: I cried all day. I cried so hard, it's nef.
by cutiee_widda_booty_15 March 18, 2010
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to screw the pooch, to really fuck up, to have a wack-off video online
by Dan Cook2 April 22, 2008
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accronym for non exciting female
if you feel 'bout woman who made you only sure to lick her cunt so you can say her a NEF woman.
by george luntz February 17, 2007
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To join a meeting under the guise of one topic, only to direct the discussion to a more entertaining (or often business-centric) conversation.
We met to discuss the audit, but he neffed the meeting and all we talked about was Monty Python
by Genevieve Magoo September 22, 2010
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A goup in chicago on the side south (43rd in federal/state) that run everything and known as (the newphews)
what's up yall know I had to rep chi-town
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