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4. NPO
Nipples Protruding Outwards
It is so cold, I have NPO
1. npo
Never Pull Out.

It can be used at any time, in any context.
Guy 1: aww man here comes that stalker girl who won't leave you alone. what are you gonna do?!

Guy 2: NPO, son
2. npo
npo stands for "nothingpersonalonline"
it's pop punk band all time low's website that allows their fans to talk major shit about their music and eachother. the site has a closenit group of regulars, the "npo hoes".
"dude! OHMYGOD! alex gaskarth so totally got on npo last night! he talked to me!"
"nahh, dude, it was a fake alex. his username had a space in it"
3. npo
medical acronym;
"nothing by mouth"
this patient is npo, do not give'em any food or drinks.
by anonymous Jun 19, 2003 add a video
5. npo
Ninja pirate ork
Check out that N.P.O.
by voodooevil Oct 17, 2003 add a video
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