Top Definition
npo
Never Pull Out.

It can be used at any time, in any context.
Guy 1: aww man here comes that stalker girl who won't leave you alone. what are you gonna do?!

Guy 2: NPO, son
by wbernard731 March 02, 2010

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npo
medical acronym;
"nothing by mouth"
this patient is npo, do not give'em any food or drinks.
by Anonymous June 19, 2003

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npo
npo stands for "nothingpersonalonline"
it's pop punk band all time low's website that allows their fans to talk major shit about their music and eachother. the site has a closenit group of regulars, the "npo hoes".
"dude! OHMYGOD! alex gaskarth so totally got on npo last night! he talked to me!"
"nahh, dude, it was a fake alex. his username had a space in it"
by jordynirene July 25, 2009

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NPO
Nipples Protruding Outwards
It is so cold, I have NPO
by Cdn EMO July 14, 2008

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npo
Ninja pirate ork
Check out that N.P.O.
by voodooevil October 17, 2003

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The Urban Dictionary Mug

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The Urban Dictionary T-Shirt

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The Urban Dictionary T-Shirt

Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).

Buy the t-shirt