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1.
NIU
Northern Illinois University, the 2nd largest institution of higher education in the state of Illinois.
NIU football rocks!
I'm going to go see my buddy at NIU this week.
by acb November 15, 2005
 
2.
an acronym for "Nigga is you serious?" It's a saying or a look you get when someone says something incredibly stupid or asinine. Something that make you wonder if their brain functions normally. Maybe they have a baby's brain.
Man #1: Yall ready to hit the club?
Man #2: Yeah dog, let's roll, tell your brother to come on.
Man #3: (walks out with a FUBU shirt on)
Man#1: NIUS!!!! We are leaving without you.
by mrholloway December 13, 2009
 
3.
NIU
It's a game in Utah, you play it like the slug bug game if you see a Nigger In Utah you call "NIU" and punch the person next to you.
Mike: "NIU!" (punches river in the arm)
River: where?
Mike: Right There, There is a whole pack of them.
River: Dammit!!
by Mike Jones777 June 05, 2010