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1.
Probably the only Pokemon that's actually cool. The only Pokemon who seeks world domination and plots for him and his clones to inherit the world. He is the most powerful of all Pokemon and can withstand anything that comes his way.
Mewtwo: Behold my powers. I am the strongest Pokemon in the world!
by Woobie May 27, 2005
 
2.
The only cool Pokemon anymore. In the first Pokemon movie he goes around killing people. That is so badass.
Mewtwo uses the power of his mind to cause havoc. Isn't that just plain cool?!?
"He even speaks english, not his damn name over and over again! lol "
-me
by Dave March 21, 2004
 
3.
Power manifested in a creature so vile, it makes you tremble to think how humans, through DNA splicing and engineering, were able to create such a monstrosity. Mewtwo is more than a pokemon, it's an example of the kind of power us humans would like to possess; that's why everyone connects with it and makes him the victor against any other creature. There's Deoxys, Lugia, Ho-oh, Groudon and Kyogre, there's Palkia, Dialga and even Darkrai but nothing really compares to the power and willingness to cause harm that Mewtwo possesses. It would be interesting though to face off Mewtwo against Arceus and witness Mewtwo obliterate Arceus from the inside out with the power of his mind done with but a single blink of his eyes!
Mewtwo concludes, "I wasn't born a Pokémon, I was created; and my creators have used and betrayed me! So, I stand alone!" Then goes on to destroy the entire facility along with everyone in it!
by Fiendermander January 09, 2008
 
4.
"Genetic Pokemon" with strong psychic powers. It was created by a scientist after years of horrific gene splicing and DNA engineering experiments.
Hooray! I just used my Master Ball and caught Mewtwo.
by Eyeballflyball July 08, 2003
 
5.
The only cool pokemon. others that are cool but not as cool as mewtwo: kabutops, articuno, lugia, deoxys and scizor. first appear in red and blue, he is the only pokemon to be at level 70 in the wild.
Ash: i tried to catch mewtwo but he tore out my testicles and replaced them with poke balls...then he stabbed me 100x with his psychicness
by Phil January 21, 2005
 
6.
1) The one Pokémon whom enjoys killing.
2) Coolest, Pokémon, EVER!
I just caught Mewtwo!
Mewtwo has a clone army!
by Crum May 22, 2004
 
7.
To be so damn wicked cool and badass,especially for a Pokemon of all things,that you got put in Super Smash Bros. Melee as a secret character.
Play 700 VS Matches or 20 hours of combined VS mode to challenge Mewtwo. And stop making DBZ jokes about him.
by 0niTTRay December 26, 2003