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1.
a very fatal, rare form of cancer. Also is the really annoying commercial.
Did you see the mesothelioma commercial? its on like every minute.
by Rlvers March 11, 2011
 
2.
Deadly form of lung cancer caused by exposure to asbestos.
That dude has mesothelioma - he's fucked.
by toddieg August 16, 2006