Mayate (noun) Share definition Flag 1.- Used by Mexicans in the southern part of Mexico (mainly Mexico DF -chilango)to demean a Homosexual or to call someone a fag. Ese guey se me hace que es un mayate... Mayate (noun) by Xprt Cop August 11, 2004 0 0 Get merch Get the Mayate (noun) mug. Buy Now — $32.95 See more merch