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2.
(Noun) the feeling of weakness you get after Nat sucks the energy from your soul because he needs it for his massive muscles
Guy 1:Man, after Nat sucked the energy from my soul for his massive muscles, I'm feeling really weak!
Guy 2: I know, fatigue sucks!
by TheEnglishDonut April 30, 2014
 
3.
being out on the block on security: lookout
Man Joe, I need to you be on fatigues tonight
by JayByrd July 03, 2006
 
4.
A group of fat people.
"that fatigue needs to go to subway not golden coral"
by Clop Placrid March 01, 2007