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1.
the act of having something.. and then suddenly not having it anymore.
It was a great loss when all my beer suddenly disappeared.
by amanda March 03, 2005
 
2.
short for: useless, worthless, stupid, retarded, etc.
omg look at tim do his donkey down the hall... what a loss.
by u all have downs August 20, 2013
 
3.
acronym for Loss Of Sandwich Syndrome. this happens when you get hungry because your girlfriend hasn't made you a sandwich yet
John was diagnosed with LOSS a half hour after he asked his girlfriend for a sandwich and she left. Luckily it wasn't fatal when a bro quickly administered a peanut butter jelly sandwich to cure Johns LOSS
by #goon12 April 18, 2012
 
4.
I'm ata loss for words why no one defined 'loss' in the Urban Dicionary. I've seen gain in the Urban Dictionary. But no 'loss' no more.
"I'm at a loss for words." never stopped anybody from saying anything.
by lossless February 11, 2004