To be down like sydrome is to be 100% on board for a plan, scheme, or invitation.
" Hey wanna go smoke a joint? " "Ya man, Im Down like Syndrome"
by John Detlor May 7, 2007
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Down Spin Syndrome is a condition someone has when they cannot counter down spin in ping pong, resulting in their attempts looking retarded.
Remember, Jeff has down spin syndrome..

What?

He looks retarded when faced with down spin..

oh yeah lol
by usemorenukes February 20, 2012
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The term of buffing a level in an attempt to make it relevant again.
"Twisted Tranquility has recently suffered from Down Bass Syndrome, what a shame."
by cirno6 November 29, 2018
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A mix between CRABS and downs and AIDS and that's all she wrote.
Why didn't you tell me about your down crabs syndrome ??
by Gucki Gang February 8, 2018
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When you feel bad and in pain and you affect all your other homies and now they're also down bad and in pain.
I have the Down Bad Syndrome bro. Gems was down bad and so was I.
by potatodarklord November 5, 2020
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A kids name vj which stands for Vincent junior. The creatures real name is Vincent's pass
Omg that kid vj is autistic cancer down syndrome brain damaged mental
by Yo mama ghhchvfdtdj March 11, 2018
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Falling Down Stairs Syndrome, or FDS, is an ailment that afflicts assclowns.

Symptoms:

Deliberate Foot-in-mouth, general clumsiness, social awkwardness, and boobery.

Secondary symptoms:

Flushed complexion, sweaty armpits, uncontrollable (and contagious) giggling.

Origins:
First diagnosed in a middle-aged man of Caucasian and Asian descent who was known to exhibit each feature of said syndrome without apparent threat to his regular physical health, despite the obvious detriment it had on his social state. Simply put, if one was to extrapolate the essence of how said Caucasian/Asian man carried out his existence, one would liken it to a human being falling down the stairs....constantly...at an extreme speed.
Hey Bro, you actually shouldn't laugh right at him because as far as we know there's no known cure for FALLING DOWN STAIRS SYNDROME (FDS); have some compassion.
by N@alie October 3, 2014
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