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1.
A verb meaning 'to influence' or 'cause change on something' . Affect is usually confused with the word effect
1. Twinkies, Ho-hos and ding-dongs will affect your heart in a a negative way

2. Not protecting your computer with an anti-virus may affect its performance due to the possible presence of many a harmful virii.
by squirrelavenger June 15, 2007
 
2.
To deeply feel something when something is said to you.
v. Yo, that affects me, you know what I'm sayin'?
by Whoak October 22, 2010