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1.
depressant

1. A chemical or substance that depresses the nervous system. e.g. alcohol.Often addictive.

2. A person who ruins everyone elses fun.

3. A relationship.

4. A member of the opposite sex.
John-"Hey whats wrong with you Timmy?"

Timmy-"I am full of this depressant," Points to a bottle of cheap vodka, "Because I'm still living with this depressant." points to expensive, unloving woman.
by Dry Rubber Chicken July 22, 2010
 
2.
someone who, when seen or spoken to, illicits a downer affect on your mood and emotions.
I was in such a great mood until I talked to Brandi. She is such a depressant.
by Scroty-G October 06, 2009