DeGregorio Share definition Flag 1. An ancient tribe of Italians specializing in the consumption of donuts, twinkies, and raw animal fat. "Damn yo, she ran that race faster than a DeGregorio swallows a box of donuts whole!" DeGregorio by The Entity May 3, 2005 0 0 Get merch Get the DeGregorio mug. Buy Now — $32.95 See more merch