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1.
DPMO is the easiest way to tell someone not to piss you off via text message, twitter, facebook etc. directed towards a specific person. acronym for Dont Piss Me Off.

can be used also with a stale face
Kianna: Tina, I had a date with Derick last night
Tina: I thought you said he cheated on you??
Kianna: I know, but now i forgive him.
Tina: DPMO.
by T. Richmond September 14, 2009
 
2.
Acronym for "Dont Piss Me Off"
Michael: "Ebony DPMO!"
Ebony: "Better to be pissed off then pissed on!"
by SanDiegoSlangz September 24, 2011