base it means, Don't.Piss.Me.Off.
by ilyttttt. January 8, 2022
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DPMO is the easiest way to tell someone not to piss you off via text message, twitter, facebook etc. directed towards a specific person. acronym for Dont Piss Me Off.

can be used also with a stale face
Kianna: Tina, I had a date with Derick last night
Tina: I thought you said he cheated on you??
Kianna: I know, but now i forgive him.
Tina: DPMO.
by T. Richmond September 14, 2009
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Michael: "Ebony DPMO!"
Ebony: "Better to be pissed off then pissed on!"
by SanDiegoSlangz September 25, 2011
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I mean it. Dpmo or you'll regret it Chelsey.
by the_small1 June 2, 2017
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Dpmo ("Don't piss me off.") can also be used in a joking way, in response to something that is gassing you up.
"Check out this girl."
"Oi, dpmo. She's built different."
by KebabShack August 29, 2021
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Some twitter user: im heated rn dpmo or ill absolutely flame u

Other twitter user: jeez ok ok go continue ur cancel thread
by yaoitank August 5, 2023
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