Dude 2: Did she work your buttons?
Dude 1: Come on man, it was our first time! Of course not!
Buttons has also become a slang term for mescaline, peyote, or psilocybin mushroom caps.
PERSON 2 - "Shit dude, were you trippin' face?"
PERSON 1 - "Na bro, I had to babysit Greg who kept telling me that he was trapped in a glass of water..."