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1.
The singular form of autistic. Usually in reference to those who play sandbox games such as minecraft other than actual autistic peoples.
Billy from down the street is an autist
by Steve the First March 29, 2011
 
2.
Loose translation for retard, which is derogatory slang for a stupid person.
Who's the autist who left the milk out?
by theVoid620 March 30, 2004