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1.
Cancer of the ass, usually caused by sitting on your ass for long periods of time. Many RuneScape nerds get this type of cancer and need chemotherapy. People known with ass cancer: Telmomarques, No Excuses, Fredmcgarry, and Rens.

Ass cancer stages:

Stage 1 - Wanting to not get up from your chair for days

Stage 2 - Twitching of the gluteus maximus

Stage 3 - Black hole appears inside of the anus and sucks in all organs causing the person to die in a matter of seconds.
Did you hear about Telmomarques getting 120 dungeoneering?
Yeah, sadly he developed stage 3 of ass cancer.
by Evil Exit August 29, 2010
 
2.
a person who keeps following you around
I seem to have developed a strange growth on my ass... my summer student is an ass cancer.
by Weppelmann February 15, 2006
 
3.
A particularly high-frequency and malodorous case of bad gas. Most often occurs among males, in the company of multiple other males, and usually after a night of heavy beer drinking. Also known as butt AIDS.
by Spalding Smails April 15, 2008
 
4.
Cancer of the ass
Terence im blessing you with ass cancer, iv just farted by the way
by Alex Broadbent January 05, 2004