Derrty South Way of saying "Hello, or greetings". Used by Houston Texas Rappers such as Lil Flip And Paul wall.
"Yo my main nigga, what it do?"

"Nuthin, just smokin a blunt the size of a 4 by 4"
by CavZzZ March 3, 2006
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"What It DO" is a term coined in The Bay Area (Oakland) CA by Oak native Keak Da Sneak Aka "Z-Kush" (also known for creatin' the term Hyphy). The Term was used to asked a Dude at a side show, what his muscle car could do? i.e Doughnuts Fishtale...ect!!! The term was later loosely used throughout the Bay Area as a term to ask a homie how he's doing. (What's up?, What's Crackin'?, What's good? What it is?...ect) Keak Coined this term before Paul wall's wack A** was even in the Rap Game! Houston Bit "What it do" from The Bay and tried to run with it and call it their own! Much like how the rest of Bay Area Slang is pirated! Slang Capitol USA is Da Bay! Frisco, Oaktown, V-Town, Sac-Town, San Jo, Da Rich... Ya'll can Borrow But GIVE CREDIT WHERE CREDIT IS DUE!!!
Original Meaning:
Ace: Yo Cutty, What It Do?
Smiley: Doughnuts Homie!

Later term:
Ace: Yo "What It Do" Homes?
Sleepy: Nothin' Homie, Just kickin' it!
by Frisco Kid! March 21, 2009
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I am in a what-to-do: whether to attend my gilrfriend's wedding or not.
by uttam maharjan December 11, 2010
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What it do Bruh(brother)? <<<<-wh/isn't your relative,3ut a friend/associate
by GrapeASU March 6, 2006
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as in whats upp or how iss you??
jerica walks in the room
alexis:what it do?!
Jerica:Nothin mutch/i`m fine`!!!
by 4rm DA b-A-y August 25, 2005
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