To Use a firearm or any weapon that uses a projectile and aim it to kill somebody. The motion of a firearm going from the side of a person and being brought up to eye level is where the term is derived from.
Yo bro hand me the blicky im finna up that
by ACeWitablick January 25, 2022
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a phrase to describe when one's patience with a topic or person has exceeded reasonable tolerance
"I've had it up to there with that class!"
by Xool314 November 16, 2011
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1. United Parcel Service - a package delivery company
2. Uninterruptable Power Supply
3. More than one up.
1. I got got my UPS package
2. I have an UPS connected
3. They went to do sit ups and then junp all the way ups.
by neorser May 20, 2006
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When somebody is fairly high, e.g. after having smoked a very strong strain, or after having smoked a few bowls in a short amount of time. Also can apply to smoking a normal amount, but taking VERY LARGE tokes.
Andrew: How high are you?
Billy: I'm up there.

Alexis: Oh. My. Gawd. Are you high, Sidney?
Sidney: ...I'm up there.
by fubsish October 19, 2009
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The direction above you, unless you are upside down.
Man, I was just sitting there and I was like, "Man, when I look up I see the sky."
by IndieBllue July 1, 2012
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to know something, to have somethin new; mostly used to brag or to tell someone they aint know sumthin

also used: up on dis
You seen my new Jacob? Thas right nigga you aint up on dis!

I been beatin your grl for months now...you jus wadnt up on dat
by CeeCee October 26, 2004
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leave from where u at
when the poleece come on the block, it's time to be up
by J Bird August 6, 2005
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