When it is the best thing you've ever eaten in your entire life.
- Man, that food was really ISSY.
by Conform January 26, 2023
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Word born in Sesto fiorentino, near Florence, it doesn’t have a specific meaning but when you say it it coveys your sense of surprise or disappointment.
It depends
Do we have a test tomorrow?

No, the teacher canceled it
Issi
by Johnnyknoxvill December 6, 2020
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an insult used when someone (me) is completely hammered
by Schubes November 15, 2004
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A retarded anime fan, usually a fan of k-pop. Used to have a past of cringe, probably still does, their music taste is literally a bunch of random genres. They like videogames and is probably a complete retard who either plays really good, or just a troll to their friends. Usually brown hair and crap colored eyes. They can be nice too, they can actually be a good friend. Usually acts cold and shy to other people, but is just retarded around their friends. They are cool with a lot of people but have a select few of best friends that share their interests. Hates parties and most real people, can kill you anytime. No really, dont piss her off.
Some dude: hey you know that weird chick over there who keeps staring at nothing, its kinda creepy. She hasn't blinked for a few minutes now

Other dude: oh that's just Issys.

Some chick: who tf is yelling about BTS, those damn chinese boys piss me off
Other chick: *sigh* that must be Issys. Wtf she's so quiet and calm looking in class, why tf are they screaming about milk?
by ThatOneKid ThatPeedInYourCerea September 15, 2018
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Is a girl that your not sure whom she really is, a girl that is in your head, and you can get her out of it, more than a friend yet may have only met once yet see her in your life as the one.
Hey, Issi- I am calling you that over the fact were dating and yet I don't know you, yet you're my lover.
Issi is a pet name for all girls that are nameless
by M. R. Duriez October 5, 2018
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She’s a fine dark girl that has nice thicc thighs like if u see her you’ll be like dayum😍 she hella freaky but low key a hoe sometimes.
Dayum he’s dating Issis he’s gonna get cheated on
by Ajdudjdhdhr March 4, 2018
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