look up any word, like fleek:
Adjective phrase, meaning not being in a state of one's normal mind. This could mean really tired, confused, insane, etc.
Joe: John just woke up, and man, he's out of it!
by USS Vagrant January 05, 2006
(UK Definition)

A colloquial, informal term for "outrageously drunk", usually used in the past tense.
Tom was absolutely out of it last night!
by 84th December 08, 2011