1. Runnin' up in yo friend's place and grabbin some delicious treats out of the frizzle.
Hey, yestaday I ran up into Jaspo's and raided his frizzle. THAT ISHT was DELICIOUS!
by Jaspo February 23, 2004
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The best teacher in the history of television. She drives a magic school bus. It's a wonder she and the other kids are still alive given what the bus has seen and done.
Ralphie: You did pass your ladybug driving test, right?
Ms. Frizzle: With flying colors!
by Secret Agent: Dog November 23, 2014
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A. (noun) Someone who is on a completely different plain of existence whether or not they're under the influence/

B. (verb) When your playing an electric instrument actively and sweat gets into the electronics a fucks them up.
A.) "I don't believe in miracles; I don't believe in lies; I don't believe in hologram; For I am the Frizzle Fry."

~Frizzle Fry by Primus

B.) Dammit, the pickups got frizzle fried from the last gig.
by Fedowicz July 20, 2018
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When someone sticks their finger in your plumbers crack and then takes a deep whiff it.
I was bending over to pick something up and my wife frizzle dipped me!
by ihdbc November 7, 2010
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using the Irmo Vernacular meaning to be incapacitated to the highest degree.
"Dude I totally got Miss Frizzled after that blunt and those jagerbombs!"
by MirMaid January 3, 2010
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