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twisted generally related to events perceived while on hallucinogenic drugs, usually referring to an individual.
"Man, last night I dropped five microdots and ran up primrose hill naked! Boy was I tweaked!"

"I was out for a stroll on primrose hill last night and I saw a naked guy running around. He looked HIGHLY tweaked!"
tweaked by Simon November 9, 2004
made by the girls of (look up) st. joseph's academy--when a girl gets eatin out
girl- omg you got tweaked?!

girl- omg he tweaked you?!
tweaked by J April 6, 2005
the word tweaked is used to describe the uncanny phenomena when your friend seems not able to behave coherently. without the use of mind altering inhibitors. he is acting a fool, and he knows it. he is tweaked.
person A: "every time you finish your work you walk around in a circle talking to yourself.. I've looked for airpods but you don't have any.."

person B: "grrr.. arg,, eugh.!"

person C: "this dude is tweaked out his mind.."
tweaked by Skylin Met Taiga April 15, 2024

tweaked out 

A person typically and habitually under the influence of cocaine, methamphetamine, diacetylmorphine, and any other tweaker choice you could think of.
Bob: Hey Jimmy see that guy over there?
Jimmy: Yeah man, he's acting pretty weird.

Bob: Eh, must be tweaked out or something .
Jimmy: On the real lets keep movin.
tweaked out by Burberry Hilfiger January 16, 2016

tweaked out 

A person doing lots of meth in a short period of time. Also known as a tweaker.
Guy 1: man Johns really tweaked out.
Guy 2: yeah I know. Hes a tweaker.
tweaked out by PinkPanada April 26, 2016

tweaked my dome 

when your dome is tweaked
ay bro u wanna skate later

i can dude i tweaked my dome
tweaked my dome by tweakedmydome77 February 14, 2017