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Military slang for "Total Inability To Support Usual Performance".
Inoperational, regardless of the reason, on either a temporary or permanent basis.
My cell phone battery is almost titsup, and I left my charger at home.

His cell phone was titsup after his ex tossed it into the hot tub.
titsup by reverb December 28, 2005
Origin: when any mammal has died and is on its back, it is "tits up". Things have gone titsup, meaning, the animal/situation has fallen down/gone wrong.
"Star Wars I, II would have been great, but Lucas became involved and the story-line went titsup!"
titsup by colby May 13, 2005
After an hour of flying the auto-pilot
went "titsup" and we crashed.
titsup by Ron May 8, 2003
computer jargon for "Total Inability To Send User Packets"
ACME Broadband,a business broadband and voice-communications provider, went TITSUP across the country at 1500 GMT after suffering a double cable strike by construction equipment. It is still fixing the broken lines. Specifically, there was a dual cable break on Britain's East coast and the London area of their national network. The company are working hard to repair the damage, and restore services.
TITSUP by Flint Mc February 4, 2020
It's like "catsup" only tastier.
Please pass the titsup.
titsup by Hugo Frankenberry June 27, 2011
A wyrdism used in irc channel #bearshare-main by wyrdjax
My connection went titsup.
titsup by Tweek October 19, 2003