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A term used in two-way radio communications meaning direct, radio-to-radio communication.
The repeater was down, so we switched to 146.52 simplex and continued to talk.
simplex by Scout 740 Baker April 16, 2004
Simple + Complex = Simplex. A problem or something else that seems simple but is complex actually.
A: It's a rather simple sum. I'll solve it easily.
B: My friend, it looks so simple but is quite complex indeed.
A: Do you mean that it's a simplex sum?
B: Yes, I do. It has both simplicity and complexity inside.
Simplex by Rajeeb2014 November 25, 2014
Person 1: Whoa for some reason that shirt looks really simple and complex at the same time.

Person 2: Yeah I know. I wore it for that exact reason. It is simplex
Simplex by Ethan Sch January 14, 2008
as in the herpes simplex, a disease you gits from ho's

a large group of simple people.
that simplex, they all got the bus into town and wus so stupid they all got the herpes simplex and the crabs from the local hookers! Then they done given it to their wives! SHIT!
simplex by Gwando November 9, 2003

sympaticus simplex 

"sympaticus simplex" is a trem coined by NNF to describe a girl who's drop-dead-gorgeous but has very simple view of the world, speaks in simple lines and has simple tastes in life in general, but that's what makes her so attractive.
She'll always be a sympaticus simplex to me.
She's gorgeous, but she's a sympaticus simplex.
She can do whatever she wants but she'll always stay a sympaticus simplex.
sympaticus simplex by NNF November 21, 2010

Herpes Simplex 08108 

When a shit show of a social media post keeps flaring up because someone else has to chime in with THEIR opinion and/or witty retort.
It burns when I pee and also when I post in Facebook Groups. The doc says I have a wicked case of Herpes Simplex 08108. I asked him why he has to be such an asshole? I got three likes for my last response and he only got two. That means I am right.
Herpes Simplex 08108 by MetaMike November 25, 2018