Something that makes absolutely no sense in the context of a sentence, story, TV show, book, play or movie. Alternatively, something that is incredibly out of place.
This term originated from Cleolinda Jones' LiveJournal recaps of the television show Lost. In one of the early episodes, the characters come across a vicious polar bear in the middle of the jungle. This animal was so out of place and out of context that in her recap, Cleolinda referred to it as the "OMGWTFPOLARBEAR".
Person 1: What is a My Little Pony doing in the middle of an action shot in Transformers?
Person 2: OMGWTFPOLARBEAR!?
an extension of the popularmockery of instant messenger acronyms. stands for 'Oh my god what the f*** massively multiplayer online Role Playing Game Barbeque.'
<Dude1> ROFL u are a hacker noob
<someone who has intelligence> OMGWTFMMORPGBBQ i dont care. get off the internet and get a life, you fat loser.